Nikolsky's sign is a skin (dermatological sign) finding in which the top layers of the skin slip away from the lower layers when slightly rubbed. When this occurs, it is a positive sign for toxic epidermal necrolysis and is associated with pemphigus vulgaris. It is useful in differentiating between pemphigus vulgaris (where it is present or positive) and bullous pemphigoid (where it is absent) The test is named after the Russian physician Pyotr Nikolsky (1858-1940).
In a study released in 1998, it was also helpful (postive) in staphylococcal scalded skin syndrome.
Autoimmune condition (Pemphigus vulgaris) Bacterial infection ( Scalded skin syndrome) Toxic drug reaction (Toxic epidermal necrolysis)